Pharmacological properties of the preparation tadalafil generic:
The active substance of tadalafil generic – tadalafil acts as a selective inhibitor of PDE-5 cyclic guanosine monophosphate. Sexual stimulation causes the release of nitric oxide, and tadalafil increases the level of cGMP in the tricky body of the penis. This helps to relax the smooth muscles of the arteries and strengthened blood flow to the tissues of the penis. Tadalafil 20mg has an effect only with sexual stimulation.
Tadalafil is a selective inhibitor of FED-5. A FED-5, in turn, is an enzyme located in the vessels of internal organs, in skeletal muscles, kidneys, platelets, and the cerebellum. Tadalafil blocks the FED-5 1000 times more than action of tadalafil FED-3, an enzyme found in the blood vessels and heart.
Tadalafil does not affect the perception of flowers. In addition, it was noted that visual acuity, pupil size, intraocular pressure did not change under the action of Cialis. In healthy individuals, tadalafil does not cause a change in systolic and diastolic blood pressure. The drug begins its action 20 minutes after admission, provided that there is sexual stimulation. The duration of action is 36 hours.
After taking tadalafil it is absorbed very quickly. The maximum concentration in the blood plasma is reached after 2 hours after ingestion. The speed and degree of absorption is not affected by eating, as well as the time of intake (morning, evening).
The volume of distribution of tadalafil generic 20mg is about 63 liters. 94% of tadalafil binds to blood plasma proteins. In healthy individuals, 0.0005% of tadalafil is detected in the sperm.
In healthy individuals, the elimination period of tadalafil is 18 hours.
Individual patient groups:
In healthy people aged 65 years, when taking the drug, low clearance of tadalafil was noted, which is expressed in an AUC increase of 25% in comparison with persons aged 19 to 45 years. This difference does not require a dose adjustment.
Indications for use:
The drug is given to patients with a diagnosis of erectile dysfunction.
The recommended dose is 20 mg. Buy generic cialis online, take inside 20 minutes before sexual activity, regardless of food intake. The effect of tadalafil generic 20mg can persist for 36 hours. The maximum frequency of application is 1 tablet per day, generic cialis tadalafil best buys.
- hypersensitivity to the active ingredient or to other components of the drug;
- concurrent use with nitrates in any dosage form.
Side effects are mild and pass independently for 2 hours. With prolonged admission Cialis side effects are reduced.
The most common: pain in the lower back, tides of blood to the face, ears, nasal congestion.
Less common: dizziness, eye pain, eyelid edema, visual disturbances, increased sweating.
Patients with cardiovascular disorders: heart palpitations, heart attacks, stroke, chest pain. However, the unambiguous relationship of these phenomena with tadalafil is not proved.
Patients with renal insufficiency in the use of tadalafil generic should be careful, as there are no clinical trials for this category in the patient. Caution in use should be shown to patients with priapism or patients with anatomical deformation of the penis.
Use with alcohol:
Tadalafil and ethanol do not affect the concentration of each other. Simultaneous reception of a significant amount of alcohol with the drug does not lead to a significant increase in blood pressure. A small number of patients showed dizziness and hypotension.
Keep Cialis in a dry place inaccessible to children, at room temperature. Shelf life – 3 years. If Cialis Instruction has not given you all the answers to your questions, you can, after reading the tadalafil generic instruction, contact our online consultant.
Men’s health is a fragile thing and many people remember it only when a problem comes up.
Now the daily stresses, the frantic rhythm of any metropolis, the fears of a crisis that have long lost their weight have already become familiar. And how about health? And that health, you can work without regretting yourself. But for everything, in due course, it is necessary to pay. And if a man disdainfully treats himself, his masculine health – the most sensitive part of the whole organism – responds quickly to this. About this few people say, but why cialis is needed erectile dysfunction to date has literally become an epidemic of both adults and young men. It turns out that a man who wants to achieve success must immerse himself in the work “with his head” and forget about his intimate life?
Fortunately, no. After all, the pharmaceutical market does not stand still, but is constantly evolving. And therefore, for a long time already known one of the most popular and effective drugs that can establish the intimate life of any man. This drug is Cialis Generic.
After the appearance of tadalafil generic it is difficult to imagine how men used to go for a steady erection, resorted to various devices, injections into the penis, prosthetics, after which the erection became permanent, all 24 hours a day.
In short, do not delay time and feel shy. It is best to act. Be healthy!