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How to take Cialis and its benefits

In the treatment of erectile dysfunction (ED), a revolution occurred with the development of type 5 phosphodiesterase inhibitors. Tadalafil (Cialis) is the newest and most versatile PDE-5 inhibitor in the clinical arsenal of treating male impotence. In pharmacies, it is sold, that is called, sin receta (without a prescription).

Pathophysiology ED has many causes, including psychological, hormonal, neurogenic, vascular, caused by drug use or cavernous impairment from any of the above factors. The most common type of ED is a mixture of psychogenic and organic causes.

In May 2002, during the 97th annual meeting of the American Urological Association in Orlando, USA, the first reports on the efficacy and duration of tadalafil ED were presented.

Tadalafil was approved for use in Europe in late 2002, and on November 21, 2003 action of tadalafil it was approved by the FDA for use in the United States.

The most unique characteristic of this drug is its long half-life (and therefore duration of action) – 17.5 hours for young men and 21.6 hours for the elderly. While the half-life of sildenafil (“Viagra”) and vardenafil ( “Levitra” ) is about 4 hours.

IMPORTANT

Clinical trials have proven the safety and efficacy of Cialis for all severity and etiology of ED, including impotence, which is difficult to medicate.

How to take “Cialis”:

  • You should not take Cialis more than once a day.
  • Always take the drug exactly as the doctor says andrologist or sexologist.
  • The maximum recommended dose of Cialis is 20 mg. The tablet is taken before sexual intercourse.
  • If you have kidney disease, the recommended dose of “Cialis” is 10 mg. This dose can be increased to 20 mg.
  • For patients with severe renal failure, 10 mg is the maximum recommended dose.
  • If you have liver disease, the recommended dose of “Cialis” is 10 mg. Patients with action of tadalafil severe hepatic impairment should be guided by their physician’s advice.
  • action of tadalafil
  • For elderly people or people with  diabetes, no special dosage is required.
  • With symptoms associated with benign prostatic hyperplasia, the recommended dose of the drug is 5 mg. Tablets are taken once a day.
  • Dosage adjustment is not required in patients with kidney disease if they do not have severe renal failure.
  • The tablet should be washed down with a full glass of water.
IMPORTANT

Tadalafil (Cialis) takes an average of 2 hours to reach its maximum concentration, compared with approximately 50 minutes for sildenafil and vardenafil.

Differences in the gastrointestinal absorption of fatty food explain different maximum plasma concentration of between three PDE5 inhibitors ( “Cialis”, “Viagra” and “Levitra”). While with the simultaneous intake of fatty foods, the effectiveness of Viagra and Levitra can be reduced, the absorption of Cialis is not affected by either fatty foods or alcohol consumption. This unique pharmacokinetic feature of  action of tadalafil Cialis is the result of a slower absorption and a longer half-life.

How the Cialis tablets work and how long the action lasts

“Cialis” is used to treat erectile dysfunction (impotence) of men.

Tadalafil, the active substance in cialis tablets, belongs to the group of drugs called phosphodiesterase type 5 inhibitors (PDE-5).

One tablet of Cialis contains:

  • 5 mg of tadalafil.
  • Non-medical ingredients: croscarmellose sodium, hydroxypropylcellulose, hydroxypropylmethylcellulose, iron oxide, lactose monohydrate, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate, talc, titanium dioxide and triacetin.
  • This medicine does not contain sucrose, gluten, tartrazine, or any other dyes.

Cialis: action description

  • The enzyme phosphodiesterase type 5  prevents erection by cleavage of the cyclic guanosine monophosphate (cGMP).
  • The substance of cGMP is needed to expand the arteries of the penis so that they are better filled with blood and supplied with oxygen.
  • Inhibitors of phosphodiesterase type 5 , such as tadalafil, do not give PDE-5 to cleave cGMP. This allows the penis to be filled with blood and stay erect long enough for sexual intercourse.

Advantage of tablets “Cialis” is that tadalafil remains active in the body much longer than other drugs. “Viagra” and “Levitra” operate for about four to five hours (and sometimes up to 12 hours). And the “Cialis” action ranges from 24 to 36 hours, so it is sometimes called “medicine for the weekend.”

Tadalafil is also used to treat the symptoms of benign prostatic hyperplasia in action of tadalafil men with an enlarged prostate. It relaxes the muscles in the prostate and bladder and helps relieve symptoms such as frequent urination, painful urination or a feeling of not completely emptied bladder. “Cialis” can be used to treat people who experience both erectile dysfunction and prostatic hyperplasia.

Frequent questions about the operation of Cialis

  1. Is Cialis harmful? 
    With an overdose – no doubt, even for perfectly healthy people. Also, it can be harmful if contraindications are indicated in the  instructions for this drug or when taking it with a medicine containing nitrates.
  2. How long does Cialis start? 
    The onset of action of tadalafil can occur 15 minutes after taking the dose, although a successful erection at this point occurs less than 40% of men. That’s why doctors do not convince patients that the effect of the drug will come very quickly, because it can take up to 2 hours before a man is able to have sexual intercourse. Unreasonable expectations from “Cialis” can cause a feeling of anxiety or loss of confidence in the doctor, which leads to ineffective treatment.
  3. Cialis does not help – what should I do? 
    The drug works only with sexual stimulation and does not increase sexual desire. If you do not get this medication, you can (after consulting a  urologist or andrologist ) use other medications, such as Cialis Soft, Viagra, Levitra or their generic (generic – a copy of the drug with the same active ingredient, but another name).

tadalafil

Tadalafil has also established itself as an effective remedy for ED caused by the treatment of prostate cancer, such as prostatectomy.

  • All available treatments for prostate cancer, including radical prostatectomy, external radiation therapy, brachytherapy, cryotherapy, etc. can lead to ED. ED after treatment of prostate cancer includes action of tadalafil organic and psychogenic causes. For example, severe anxiety and depression action of tadalafil can lead to psychogenic ED.
  • Tadalafil and other PDE-5 inhibitors were dosed both on a continuous basis and on demand, were proposed for the treatment of erectile dysfunction and prevention of ED after prostatectomyIn a small prospective observational study, 27 patients who underwent prostatectomy received tadalafil 20 mg every 3 days, starting from the first postoperative day (Carson et al 2005).
  • After 6 weeks, 89% of men reported having an erection, and 50% had a successful sexual intercourse.
  • After 6 months, the number of patients able to successfully have sex increased to 78%.

Forms of production of the preparation “Cialis” and dosages for “Cialis” 20 mg, “Cialis” 5 mg, “Cialis” 40 mg

There are following forms of release of the preparation “Cialis”:

  • “Cialis” 2.5 mg  – yellow-orange, almond-shaped, coated tablets, engraved on one side “C2½”. Contain tadalafil 2.5 mg.
  • “Cialis” 5 mg (for use once a day) – yellow, almond-shaped tablet with film coating, marked on one side of the “C5”. Contain tadalafil 5 mg.
  • “Cialis” 10 mg  – each yellow, almond-shaped tablet with film coating, marked on one side of the “C10”, contains tadalafil 10 mg.
  • “Cialis” 20 mg  – in the photo it can be seen that these are orange, almond-shaped tablets with film coating, marked on one side of the “C20”. Contain tadalafil 20 mg.
  • “Cialis”: course treatment with erectile dysfunction

    • 10 mg or 20 mg of the drug should be taken at least  30-60 minutes before the expected sexual activity. The amount of time necessary for the drug to work varies from person to person. Some men Cialis begins to act 16 minutes after taking the pill, but for the first time it is recommended to take it at least an hour before sex.
    • Cialis is effective for 36 hours , that is, after taking it, you can achieve an erection (with sexual stimulation) at any time for 36 hours.
    • cialisPreparations related to inhibitors of PDE-5 are intended for regular episodic administration. A certain course of “Cialis”, “Viagra” or “Levitra” does not exist.
    • Many things, such as body weight, illnesses and taking medications, can affect the dose of medicine a person needs. If your doctor recommends a dose different from that indicated in the article, follow the advice of the doctor.
    • After three months of taking Cialis, erectile function is improved in the form of spontaneous erections. If ED is caused by psychological problems, the improvement is due to increased confidence in their sexual abilities.

    So far, “Cialis” is the only cure for impotence, a low dose of which is suitable for daily use. The initial dose is 2.5 milligrams; if this does not work, the daily dose may be increased to 5 mg.

    The decision to use lower doses of “Levitra” or “Viagra” will be reckless, since there is no available data on the effectiveness of this method.

    Side effects:

    • “Cialis” works by relaxing the smooth muscle cells, which dilates the blood vessels – mainly in the penis, but also in other parts of the body. The most common side effect when taking “Cialis” is a headache, which occurs in 16% of men .
    • Other reactions include: redness of the skin, indigestion, nasal congestion and urinary tract infections. But when the drug is used properly, these side effects are relatively weak, and most action of tadalafil of them will disappear after a few hours.
    • In rare cases, men experience temporary, light eye problems due to reduced blood flow to the optic nerve . Basically, a blue tint appears in the objects, as well as an increased sensitivity to light and blurred vision. Nevertheless, people with pigment retinitis, a rare eye disease, should be action of tadalafil very careful when using Cialis.
    • Sudden hearing loss is another rare side effect of PDE-5 inhibitors.

    A large, randomized, double-blind, placebo-controlled trial involving 2,102 men showed that tadalafil is well tolerated. Fifty-one percent of men using tadalafil (20 mg) experienced at least one adverse event, but only 3.2% discontinued treatment.