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Features of Tadalafil, history of the creation

Sexual disorders are a scourge of millions of men. They seriously hamper the management of the couple’s natural intimate life. The most common violation of the reproductive system of a man is a weak erection, which has the scientific name erectile dysfunction. However, these days, thanks to effective medicines, one can cope with this problem. One of those is Cialis, the basis of which is tadalafil. Instructions for the use of the drug and its features are a topic that we will consider today.

The history of the appearance of Tadalafil

In 1993, ICOS and Lilly began a series of studies to develop drugs to enhance erection. Scientists have studied the effect of the chemical compound IC-351, which retards the action of the enzyme phosphodiesterase type 5. It is this enzyme that is the basis of all modern drugs for the treatment of erectile dysfunction. In 1995, ICOS obtained a patent right for IC-351 and started a clinical trial of the facility. In July 2002, the drug was recommended for sales in the EU countries. Generic Tadalafil is sold under the trade name Cialis. creation of cialis

Principle of action of generic Tadalafil

Tadalafil belongs to the type of selective inhibitors of type 5 phosphodiesterase. He takes an active part in inhibiting the synthesis of cGMP – this allows you to relax the smooth muscles of the blood vessels in the pelvic area and genitals. This action leads to an increase in the blood flow to the cavernous bodies of the penis, after which the male experiences a prolonged quality erection.

The main advantage of generic tadalafil 20mg is its long-lasting effect. The effect occurs approximately 15-20 minutes after taking and remains for the next 36 hours. Maximum efficiency is observed after 5-6 hours after use. After that, its gradual elimination from the body begins. Generic Tadalafil favorably differs from other drugs for the treatment of weak erections – it lasts a day and a half. No other drug can boast of such an achievement.

With tadalafil man can achieve increased erections and have sex from 30 minutes and longer. But this is not all the advantages of Tadalafil. Its main active ingredient is effective only if the man is sexually aroused. This means that an erection will appear exactly at the moment when it is necessary for sex, that is, at the request of a man. Tadalafil excludes the existence of a permanent erection during all 36 hours of action on the body.

Instructions for the use of Tadalafil

Tadalafil can not be taken more than once a day, it does not matter, in the form of tablets, capsules or

generic tadalafil

gel. At the first use of the drug, the recommended dose is 2.5 mg., With time it can be increased to 40 mg. The most optimal dose of tadalafil is 20 mg. Both in the form of tablets, and in the form of capsules/gel. Depending on how the body reacts to tadalafil, the dosage can be from 2.5 to 40 mg.
Tadalafil is used regardless of the time of eating. It is advisable to apply the medicine at the same time of day. If a man leads an active sex life (has sex more than 2 times a week), then Tadalafil must be consumed every day. If the number of sexual acts is less than 2 times a week, then use tadalafil follows about 1 hour before intimacy.
Tadalafil in tablets and capsules is washed down with any non-alcoholic liquid, but tadalafil in the form of a gel should be simply swallowed. Tablets and capsules can be either tasteless or bitter. Therefore, many men prefer to eat a gel that has several flavor options – raspberries, strawberries, mangoes and others.

Contraindications to the use of Tadalafil

Tadalafil is an effective substance for the treatment of weak erections. However, he, like any other medicine, has his own contraindications.

You can not take Tadalafil 20mg in the following situations:
• cardiovascular diseases – chronic heart failure of grade 2-4, uncontrolled arrhythmia, hypotension (with a pressure level of less than 90/50 mm), ischemic stroke and myocardial infarction that have occurred in the last 6 months, uncontrolled hypertension, attacks of angina during sexual activity, unstable angina;
• priapism;
• anatomical deformation of the genital organ – cavernous fibrosis, angular curvature, Peyronie’s disease;
• Tadalafil can not be taken together with organic nitrates, donators of nitric oxide, alpha-adrenoblockers, potent inhibitors of the isoenzyme CYP3A4 and drugs for the treatment of erectile dysfunction;
• a high degree of sensitivity of the body to the ingredients of generic Tadalafil 20mg;
• loss of vision due to ischemic anterior neuropathy of the optic nerve;
• lactose intolerance, lactase deficiency, glucose-galactose malabsorption;
• a drug can not be taken by women and minors (under 18 years of age).

What are the side effects of Tadalafil?

Negative reactions of the body to the use of tadalafil often have an average and weak degree of severity. Most often, they appear after the first use of the drug and subsequently decrease as Tadalafil continues to use. The most common side effects are:buy generic cialis

• Headache – 11% of cases;
• indigestion – 7%.

Possible side effects include:

• The flush of blood to the face and its redness;
• backache;
• congestion of the nasal cavity;
• myalgia.

Rarely from admission generic Tadalafil in humans appear:

• Pain in the eyes;• dizziness;
• Edema of the eyelids;
generic tadalafil• migraine.

Very rarely Tadalafil becomes the cause:

• priapism;
• Blurry vision;
• rashes on the face;
• edema of the face;
• hypertension;
• stomach ache;
• Erection delay.

How long can I take Tadalafil?

Getting rid of erectile dysfunction implies the passage of a man with a course of treatment with tadalafil. Its terms are determined by the doctor, who also prescribes the dosage of the drug. Most often the treatment consists of daily use of generic Tadalafil for 30 days, the dosage of which does not exceed 20 mg.
However, according to the doctor’s decision, the timing of the course of treatment can be reduced or increased. Therefore, before using Tadalafil it is necessary to consult a doctor. If a man decides to use tadalafil on his own, then you need to know that it can not be taken continuously for more than 1 month. After a daily 30-day session, you should take a break for 1 month.